CINGAL®

What is CINGAL®?

CINGAL® is a hyaluronic acid gel containing micronized steroid particles. In patients who are unresponsive to pain medications (or conservative non-pharmacologic therapy), CINGAL® is injected intra-articularly to treat knee pain associated with osteoarthritis (OA). This orthopedic injection is manufactured by Anika Therapeutics, Inc., a Bedford-based pharmaceutical company.

Additionally, Cingal injection stands out by combining a corticosteroid and a hyaluronic acid (HA) formula into a single injection, providing patients with dual benefits. This unique formulation offers immediate and long-term relief by addressing inflammation and improving joint lubrication.

What are the features of CINGAL knee injection?

• Higher efficacy: This cortisone-containing formulation is clinically proven more effective than hyaluronic acid alone.
• Dual action formulation: CINGAL® contains two different pain-relieving ingredients, which work synergistically to provide rapid, lasting symptomatic relief.
• Fast acting and long-lasting pain relief: These CINGAL treatments have demonstrated effective outcomes for up to six months.
• Quick procedure: Like Anika Therapeutics’ Monovisc, CINGAL only requires a single viscosupplement injection to achieve optimal treatment outcomes. Patients need a quick visit to the clinic and less than an hour of administration to feel the relief improvements.

What accessories/items come with CINGAL®?

• 1 4 mL sterile pre-filled syringe
• One package insert
• One traceability label

How does CINGAL® work in knee pain?

CINGAL® works by replenishing the synovial fluid in the knee joint, restoring lubrication. It also cushions the affected joint, helping to prevent disease progression that may result in total knee replacement surgery. At the same time, the HA and corticosteroid formulations can offer short-term pain relief by mitigating cartilage inflammation and reducing swelling.

What are the ingredients of CINGAL injection?

• Sodium Hyaluronate (88.0 mg)
• Triamcinolone Hexacetonide (18.0 mg)
• Polysorbate 80 (8.0 mg)
• Sorbitol (200.0 mg)
• Sodium Phosphate, Monobasic (1.2 mg)
• Sodium Phosphate, Dibasic (6.0 mg)
• USP water for injection

How long do results last?

According to various patient testimonials and experiences, CINGAL treatment can offer at least six months of symptomatic relief. This highly effective injection provides long-lasting pain relief with a single-injection therapy. They can enjoy improved joint health and mobility after the CINGAL injection treatment.

What is the expected recovery time for my patients?

Due to its minimally invasive nature, CINGAL® generally does not need recovery time. Patients can return to their daily activities immediately while adhering to the medical professionals’ post-treatment instructions for a safe and effective treatment.

What are some important safety tips to follow when using this product?

• Do not administer CINGAL® to pregnant patients (or those who suspect they might be pregnant).
• Avoid injecting CINGAL® into the knees of patients who have skin diseases or infections in the area of the injection site.
• Do not administer CINGAL® to patients with known allergies to hexacetonide preparations or HA preparations.

What are the most common side effects?

• Facial flushing
• Injection site pain
• Edema
• Erythema
• Arthralgia
• Effusion
• Local swelling
• Arthropathy
• stiffness of the knee
• Skin atrophy
• Post-injection flare
• Hypopigmentation
• Calcification