NUCLEOFILL™ STRONG

NUCLEOFILL™ STRONG Product Summary

NUCLEOFILL™ STRONG is a high-performance bio-restructuring injectable gel formulated with 2.5% polynucleotides for the treatment of severe skin aging, sagging, and deep wrinkles. It stimulates skin regeneration at a cellular level, targeting both superficial and deep tissues for long-lasting improvements in elasticity and hydration.

• Type: Polynucleotide-based biostimulant gel.
• Target Use: For advanced aging and structural skin support.
• Packaging: Pre-filled syringe (1.5 mL) with 30G needles included.

NUCLEOFILL™ STRONG Key Features and Benefits

NUCLEOFILL™ STRONG delivers intensive skin rejuvenation by targeting key areas of dermal and subcutaneous support.

• Enhanced Hydration: Deep and long-lasting water retention enhances skin hydration.
• Intense Lifting Effect: Promotes fibroblast maturation into myofibroblasts, resulting in a lifting and tightening effect.
• Collagen Stimulation: Boosts production of Type I collagen and elastin for improved dermal structure.
• Tissue Regeneration: Stimulates adipose and bone tissue repair, restoring skin volume and support.
• Advanced Oxidative Protection: Neutralizes free radicals, reducing oxidative stress.

NUCLEOFILL™ STRONG Composition

The advanced formulation ensures optimal bioavailability and tissue integration.

• Polynucleotide Concentration: 2.5%.
• Molecular Weight: 2,500 kDa for effective dermal activity.
• Viscosity: 48–65 Pa*s for stability and ease of application.
• pH: 6.8–7.5 for physiological compatibility.

NUCLEOFILL™ STRONG Intended Purpose / Indications

NUCLEOFILL™ STRONG is designed for the treatment of advanced signs of aging and severe skin damage.

• Primary Indications:
  • Deep wrinkles and severe skin laxity.
  • Signs of oxidative stress and advanced skin aging.
  • Depressed scars, including surgical scars.
• Targeted Treatment Areas:
  • Face: Jawline, nasolabial folds, cheeks, and under-eye area.
  • Body: Décolleté, neck, and hands.

NUCLEOFILL™ STRONG Injection and Treatment Areas

This product is suitable for deep tissue rejuvenation and structural support.

• Injection Areas:
  • Facial zones like under-eye hollows, nasolabial folds, and jawline.
  • Body regions such as the neck and chest.
• Injection Depth: Deep dermis, subcutaneous layers, or adipose tissue for optimal bio-restructuring.

NUCLEOFILL™ STRONG Reconstitution and Preparation Guidelines

NUCLEOFILL™ STRONG is pre-filled and requires no reconstitution, ensuring sterility and convenience.

• Preparation Instructions:
  • Open the sterile packaging under aseptic conditions.
  • Attach the provided 30G needle to the syringe securely.
  • Check for clarity and absence of particulates before use.

NUCLEOFILL™ STRONG Administration and Dosage

Precise administration techniques maximize efficacy while ensuring patient safety.

• Injection Techniques:
  • Multi-point or linear threading techniques for even application.
  • Deliver 0.1 mL per injection point, spaced 1 cm apart.
• Dosage:
  • A typical session uses 1.5 mL per area, adjusted based on the treatment plan.
  • Initial protocol includes 3 sessions spaced 15–30 days apart.

NUCLEOFILL™ STRONG Storage Instructions

Proper storage ensures the product’s stability and effectiveness.

• Store at 2–30°C in a dry, cool environment.
• Avoid freezing and exposure to direct sunlight.
• Verify the expiration date before administration.

NUCLEOFILL™ STRONG Contraindications

Avoid use in certain conditions to ensure safety and efficacy.

• Do Not Use:
  • In patients allergic to polynucleotides or other product components.
  • On areas with active skin infections or inflammation.
  • During pregnancy or breastfeeding.
  • In patients with autoimmune diseases or severe chronic illnesses.

NUCLEOFILL™ STRONG Precautions and Warnings

Adhering to safety guidelines minimizes risks and optimizes outcomes.

• Avoid injecting into vascular-rich areas to prevent intravascular complications.
• Refrain from combining with other aesthetic procedures during the same session.
• Conduct a thorough patient history to evaluate suitability and risks.

NUCLEOFILL™ STRONG Post-Treatment Care

Following post-treatment recommendations enhances results and minimizes recovery time.

• Aftercare Recommendations:
  • Avoid applying makeup for 12 hours post-procedure.
  • Protect treated areas from UV exposure, extreme temperatures, and strenuous activities for 48 hours.
  • Use a gentle skincare routine, including daily application of SPF 50 sunscreen.

NUCLEOFILL™ STRONG Side Effects and Adverse Reactions

This treatment is well-tolerated, with side effects being mild and transient.

• Common Side Effects:
  • Redness, swelling, and tenderness at the injection site.
  • Minor bruising or itching, resolving within a few days.
• Rare Reactions:
  • Small nodules or discoloration, typically self-limiting.

NUCLEOFILL™ STRONG Patient Eligibility

NUCLEOFILL™ STRONG is ideal for individuals with advanced skin aging and structural concerns.

• Ideal Candidates:
  • Adults with severe wrinkles, skin sagging, or loss of volume.
  • Those seeking non-surgical solutions for tissue repair and skin tightening.
• Not recommended for individuals under 18 years or those with unrealistic treatment expectations.

NUCLEOFILL™ STRONG Follow-Up and Maintenance

Regular follow-ups and maintenance sessions ensure prolonged benefits.

• Protocol:
  • Initial series: 3 sessions spaced every 2–4 weeks.
  • Maintenance: One session every 4–6 months, depending on individual needs.

NUCLEOFILL™ STRONG Manufacturer and Regulatory Information

NUCLEOFILL™ STRONG is developed by Biosimil Aesthetics, a leader in innovative polynucleotide-based skincare products.

• Certifications: CE-marked for safety and efficacy.
• Manufacturer: Biosimil Aesthetics, adhering to stringent quality standards.