DUROLANE®

What is DUROLANE® 60mg/3ml?

DUROLANE® 60mg/3ml is a clear, viscous injectable gel consisting of highly purified hyaluronic acid. Clinically, DUROLANE® 60mg/3ml is indicated for the treatment of knee pain in osteoarthritis in those who have responded inadequately to simple analgesics like acetaminophen or conservative non-pharmacological therapy. DUROLANE® 60mg/3ml is a product of Q-Med AB.

What are the features of these DUROLANE injections?

• Safe Formulation: DUROLANE® 60mg/3ml has obtained FDA approval for use. Its safety has been extensively tested in clinical studies.
• NASHA Technology: The naturally entangled hyaluronic acid chains in DUROLANE® are stabilized using the innovative NASHA technology.
• Ingredients of Non-animal Origin: The hyaluronic acid in the injectable fluid is bio-synthesized through bacterial fermentation. It is not known to cause immunogenic reactions.
• Convenient and Minimally Invasive: Compared to other HA injections for knee OA, DUROLANE provides a single-injection therapy that requires no downtime.

What accessories/items come with the package?

• 1 prefilled 3 ml glass syringe
• 1 package insert

How does DUROLANE work for knee pain?

These injections of DUROLANE work in two ways: cushioning and lubrication using hyaluronic acid for the joints. This prevents the bones from rubbing together, resulting in discomfort and limited mobility. DUROLANE provides symptomatic relief, reducing joint pain and inflammation caused by knee osteoarthritis.

What are the ingredients of this product?

DUROLANE injections boast a unique formulation, requiring only a single hyaluronic acid injection into the affected knee joint. Bioventus ensured that DUROLANE effectively addresses knee OA without compromising the patient’s health with these potent and safe components.

• Stabilized Sodium Hyaluronate (20mg)
• Sodium Chloride (9mg)
• Potassium Dihydrogen Phosphate (0.03mg)
• Disodium Hydrogen Phosphate Dihydrate (0.14mg)
• Water for Injection

How long do results last?

DUROLANE® 60mg/3ml is formulated to deliver durable results, providing prolonged pain relief in joints. Patients can expect that after the injection session, symptomatic relief of DUROLANE works for up to six months or more. This may depend on the severity of the knee OA condition of the patient, overall health, and other individual factors.

What is the expected recovery time for my patients?

DUROLANE® is administered via minimally invasive injection and requires minimal recovery time. Its quick injection procedure may appeal to knee OA patients with time constraints, as it only requires 30 minutes to an hour.

What are some important safety tips to follow when using this product?

• It is essential to remove any joint effusion before administering DUROLANE®.
• The effectiveness and safety of DUROLANE® 60mg/3ml in joints other than the knee have not been established. Do not inject DUROLANE® 60mg/3ml extra-articularly, intra-vascularly (or in the synovial capsule/tissues).
• Do not use DUROLANE® 60mg/3ml concomitantly with disinfectants that contain quaternary ammonium salts (sodium hyaluronate may precipitate in their presence).
• If your patients are allergic to hyaluronic acid preparations, do not administer DUROLANE® 60mg/3ml.

What are the most common side effects?

Understanding the common DUROLANE side effects can help patients build trust in the product and make informed decisions about their knee OA conditions. According to the prescribing information, DUROLANE injections reportedly have these typical reactions post-treatment.

• Pain
• Joint Pain
• Joint Swelling
• Joint Stiffness at the Injection Site

Most of these reactions are mild to moderate and may not require a doctor’s visit. However, patients must seek immediate medical attention for prompt action when these worsen or persist.